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Citicoline Sodium Powder
2、Specification:99% HPLC
3、Appearance: White Crystalline Powder
4、CAS NO.: 33818-15-4
5、Lead time: 3-7 Working Days
6、Package: 12kg/drum, 27 drums/tray
7、Main Market: North America, Europe, Switzerland, South Africa, Southeast Asia, Australia, etc.
8、Certification: cGMP,Kosher, Halal, BRC, Organic, ISO9001, ISO22000, etc
9、Europe Warehouse/America Warehouse
- Product Description
Citicoline Sodium Powder (CDP‑Choline Sodium) cGMP Nutraceutical API | Hongda Phytochemistry
Pharmaceutical-Grade Ingredient for Brain Support
Do you require citicoline sodium powder for your nervous system products and are looking for a reliable supplier? Shaanxi Hongda's citicoline sodium is cGMP certified and meets stringent USP/EP stability and purity standards, with HPLC testing showing a purity of up to 99%. Sodium CDP‑Choline powder is one of our high‑volume cGMP‑manufactured API‑grade raw materials, widely procured by supplement manufacturers, formulation labs and pharmaceutical ingredient distributors across North America, Europe, Australia and Southeast Asia.
CDP choline powder is the monosodium salt form of CDP‑Choline. Compared to free‑base citicoline, the sodium‑salt structure delivers improved water‑solubility and better physical stability for industrial blending and solid‑dosage manufacturing.Our pure citicoline monosodium salt, as an important nootropic molecule, can "energize" the brain (increase signal transmission speed) and "repair" nerve cell membranes, promoting the production of hormones and phosphatidylcholine, enhancing brain function, and helping to reduce the risk of Alzheimer's disease and stroke.
Unlike cheaper choline supplements, its sodium salt form ensures 98%+ bioavailability for rapid absorption
Request Samples｜Download Specification Sheet
What Makes Our Citicoline Sodium Powder Different
Citicoline sodium powder factory/Citicoline sodium powder suppliers/Citicoline sodium powder manufacturers
Strict ICH‑aligned impurity & residual‑solvent management
Related‑substances and residual‑solvents are top audit items for western supplement and pharma factories. Each batch executes full ICH Q3A / Q3B / Q3C / Q3D testing. Impurity‑profile reports can be shared for your supplier‑qualification audit.
Tunable physical‑properties for your production line
Poor bulk‑density or inconsistent particle size creates filling deviation during high‑speed encapsulation / tableting. We can adjust particle range and bulk density according to your equipment parameters, lowering your excipient‑adjustment workload.
Stable large‑volume capacity plus overseas local stock
This is our high‑turnover staple API. Annual production capacity >50 metric tons. We hold inventory buffer at China factory plus US / EU warehouse stock. Shorten lead‑time for urgent orders; pre‑production sample confirmation supported for container‑scale projects.
Comprehensive regulatory‑support documentation
Each shipment delivers lot‑matched COA with HPLC chromatogram, heavy‑metal, endotoxin, microbial report and SDS. We maintain FDA DMF file (DMF:25796); can issue Letter‑of‑Authorization (LOA) for your regulatory submission. Non‑GMO, allergen‑free statements, Kosher / Halal documents available subject to batch conditions. Real‑time & accelerated ICH Q1A stability data available upon request.
Specifications
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Item of Test
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Limits of Test
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Results of Test
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Appearance
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White crystalline or crystalline powder
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Conform
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Assay by HPLC
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≥98%
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99.85%
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Identification
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(1)A green colour is produced
(2)The retention time of the principal peak in the chromatogram obtained with the test solution is identical with that of the principal peak in the chromatogram obtained with the reference solution
(3)The infrared absorption spectrum is concordant with the standard spectrum.
(4)The aqueous solution yields the reaction (1)characteristic of sodium salts.
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Complies
Complies
Complies
Complies
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pH
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6.0---7.5
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6.9
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Clarity, color of solution
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Clear, colorless
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Complies
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Chloride
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≤0.05%
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Complies
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Ammonium salt
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≤0.05%
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Complies
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Iron salt
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≤0.01%
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Complies
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Phosphate
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≤0.1%
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Complies
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Related substances
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5'-GMP≤0.3%
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0.006%
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Single impurity ≤0.2%
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0.006%
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Total Another Impurity≤0.7%
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0.02%
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Residual solvents
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Limit of methanol≤0.3%
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Undetected
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Limit of ethanol≤0.5%
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Undetected
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Limit of acetone≤0.5%
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Undetected
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Loss on drying
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≤6.0%
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0.8%
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Heavy Metals
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≤5ppm
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Complies
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Arsenic salt
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≤0.0001%
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Complies
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Endotoxin
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<0.30EU/mg
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Complies
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Limit of microbe
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Total bacterial count≤1000 CFU/g
Yeast & Mold≤100 CFU/g
E. Coli: Negative
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< 10 CFU/g
< 10 CFU/g
Undetected
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Conclusion
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The product meets with the CP2020 standard.
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Send us your inquiry to get COA:duke@hongdaherb.com
Core Synthesis & Purification Process
Most quality deviations of citicoline sodium originate from incomplete synthesis, insufficient purification and improper drying leading to hydrolysis. Our full‑control workflow addresses these known failure points:
- Incoming raw‑material qualification All synthesis starting materials go through identity, impurity and heavy‑metal testing. Non‑compliant lots get rejected before entering production.
- pH‑controlled synthesis reaction Reaction runs under tightly controlled temperature and pH parameters to minimise generation of by‑product related‑substances.
- Multi‑step purification & recrystallization Multiple rounds recrystallization to strip reaction impurities and residual organic solvents, aligned with ICH guidelines.
- Controlled low‑temperature drying Carefully managed drying cycle to avoid thermal‑driven hydrolysis; strictly monitor loss‑on‑drying index.
- Milling & particle‑size homogenization Adjust particle distribution and bulk density, optimise powder handling for capsule filling, tableting and multi‑ingredient premixing.
- Full‑panel batch release testing Every batch completes full‑panel QC: identity via HPLC & IR, assay, related‑substances, residual solvents, endotoxin, heavy‑metals and microbial testing.
- Inert‑gas sealed packaging Nitrogen‑flushed inner bags reduce moisture‑and‑oxygen exposure during ocean transit. Custom protective packing for tropical high‑humidity destinations.
Why Your Brain Loves Citicoline
When stress or aging hits your cognitive health, Citicoline Sodium works like a "neuron repair kit":
🔋 Fuels Mental Energy: Citicoline is a precursor to key brain phospholipids, which is converted to cytidine and choline in the brain.
🛡️ Shields Neurons: Shaanxi hongda's Citicoline Sodium 98% API Powder Reduces post-injury brain edema by 40% in trials
🧠 Sharpens Recall: Meta-analysis shows that 72% of patients with vascular cognitive impairment have improved memory after taking citicoline sodium
Application: Citicoline sodium powder for sale is often used in tablets or capsules to treat neurological sequelae caused by craniocerebral injury or cerebrovascular accident.
Quality Assurance
- Manufactured in FDA-inspected, cGMP facilities
- Full ICH Q3D elemental impurity compliance
- Batch-specific COA with HPLC chromatograms
- Available accelerated stability data
Sustainable Production
We employ a fully enclosed production cycle that meets environmental requirements, reducing our environmental footprint and helping your brand achieve carbon neutrality goals.
Customized Services(Citicoline sodium factory/Citicoline supplier)
We offer:
Hot sale cytidine diphosphate choline sodium salt + caffeine + L-theanine, providing long-lasting support through CDP-Choline to buffer the anxiety caused by caffeine.
Citicoline sodium + phosphatidylserine (PS) + ginkgo extract, supporting nerve membrane repair and microcirculation through multiple pathways.
Combined with Hericium erinaceus extract, it induces a synergistic effect by inducing nerve growth factor (NGF) and providing phospholipid raw materials.
Packaging & Shipping Information
‑ Standard packing: 12 kg / 25 kg net weight fibre drum, nitrogen‑flushed inner aluminium foil bag.
‑ Storage guidance: Keep drums sealed in cool, dry, dark warehouse. Avoid heat, humidity and frequent repeated opening of drum. Consume rapidly once opened.
‑ Shipping option: Ex‑factory China, or ship from our US / EU local warehouse. Enhanced moisture
‑resistant packing is recommended for tropical humid regions.
‑ Lead‑time: Ex‑China stock 7‑12 working‑days; local overseas warehouse orders subject to stock status; custom particle‑spec batches require extended production cycle.
FAQ
Q: What is the difference between Citicoline Sodium and Citicoline free‑base powder?
A: Citicoline Sodium (CAS 33818‑15‑4) is monosodium salt form; free‑base Citicoline (CAS 987‑78‑0) is non‑salt molecule. Sodium‑salt variant brings better water‑solubility and powder‑state stability. Please clarify salt‑type requirement in your inquiry to avoid order mismatch.
Q: Will particle & bulk‑density variation cause filling deviation during mass production?
A: Our homogenised batches keep tight physical‑property control. We strongly recommend customers perform small‑scale formulation trial before full‑scale manufacturing, as final performance also depends on your excipients and workshop humidity.
Q: What certifications back your Citicoline Sodium?
A: We hold EU GMP, ISO 13485, and FDA DMF #25796, with third-party testing by Eurofins and SGS.
Q: Can I get less than 25kg for clinical trials?
A: Yes – we supply R&D quantities from 5kg with same-week shipping.
Q: How is stability data provided?
A: Each batch ships with ICH Q1A-compliant reports covering 25°C/60% RH for 36 months.
Q: Do you assist with regulatory submissions?
A: We provide open-access DMFs, CEPs, and impurity profile cross-references for 15+ agencies.
Q: What’s your lead time for 500kg orders?
A: Stock available in 7 days; non-stock batches shipped in 4–5 weeks.
Request Samples or Discuss Projects
Free API Samples: Test our Citicoline Sodium Powder (2kg minimum, COA included).
Technical Consultation: Schedule a call with our neuropharmacology experts.
📩 Contact: duke@hongdaherb.com | 📞 Live Chat Support
