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S Adenosyl Methionine Powder
2、Specification:99% HPLC
3、Appearance: White Powder
4、CAS NO.: 485-80-3
5、Lead time: 3-7 Working Days
6、Package: 12kg/drum, 27 drums/tray
7、Main Market: North America, Europe, Switzerland, South Africa, Southeast Asia, Australia, etc.
8、Certification: cGMP,Kosher, Halal, BRC, Organic, ISO9001, ISO22000, etc
9、Europe Warehouse/America Warehouse
- Product Description
Premium S-Adenosyl Methionine (SAMe) Powder | cGMP Certified | >99% Purity
Shaanxi Hongda Phytochemistry Co., Ltd. is a leading manufacturer of high-quality nutritional supplement raw materials, specializing in the production of high-purity S Adenosyl Methionine Powder (SAMe). S-Adenosylmethionine (SAMe) participates in over 100 core biochemical reactions in the body. It not only acts as a "happy catalyst" by promoting the synthesis of dopamine, serotonin, and norepinephrine through transmethylation, naturally alleviating depressive moods, but also generates endogenous glutathione through transsulfation, serving as a clinical-grade detoxification center against fatty liver and drug-induced liver damage. In the field of joint health, it can spontaneously stimulate chondrocytes to synthesize glycosaminoglycans (GAGs), fundamentally repairing worn cartilage tissue.
If you need technical specs or bulk pricing (minimum order quantity of 1 kg), please email our experts at duke@hongdaherb.com.
We present you with transparent product standards:
1. Effective (S,S) configuration stereoisomer ratio limit locked ((S,S)-SAMe > 70%): Only the (S,S) form of SAMe possesses transmethylation activity. Hongda utilizes a special chiral HPLC system to precisely measure each batch of bulk products, ensuring that the content of truly active cis (S,S) isomers is greater than 70%, rejecting the use of inactive (R,S) trans components, and ensuring that the final product possesses extremely strong "explosive power."
2. Dual-acid multi-site lattice nesting technology: Addressing the critical weakness of SAMe's heat sensitivity and easy degradation, Hongda employs a liquid-phase crystal recombination process to allow one SAMe molecule to form a tight charge-self-assembled lattice with two sulfate ions and one p-Toluenesulfonate molecule. This multi-site lattice anchoring structure increases the chemical decomposition activation energy of the molecule by more than 40%. Under dry and sealed conditions at 25℃, the degradation rate of the active ingredient is less than 5% within 24 months, completely eliminating the nightmare of returned products that turn black, soften, and become ineffective.
3. Deep separation of trace amounts of free toluenesulfonic acid and sulfate: Free acid content is less than 0.5%. Through multi-stage countercurrent liquid phase ultrafiltration washing, unbound free toluenesulfonic acid is reduced to below 0.5%, minimizing gastrointestinal irritation.
4. High-barrier moisture-proof crystal particle size modification: Hongda controls the crystal growth axis to produce regular short columnar crystals with no pinholes or voids. The ratio of compacted to loose density prevents degradation during the coating process due to water seepage.
Technical Specifications
Item of Test | Limits of Test | Results of Test |
Appearance | Off-White Powder | Conform |
Assay by HPLC | ≥95% | 99.5% |
Sulphated Ash | ≤0.5% | 0.1% |
Water | ≤3% | 1.5% |
S, S-Isomer (HPLC) | ≥75% | 81% |
SAM-e ION (HPLC) | 49.5 - 54.7% | 51.5% |
P-Toluenesulfonic Acid | 21.0%–24.0% | 22.8% |
Content of Sulfate (SO4) (HPLC) | 23.5%–26.5% | 25.4% |
S-Adenosyl-L-Homocysteine | ≤1.0% | 0.05% |
Adenine | ≤1.0% | 0.3% |
Methylthioadenosine | ≤1.5% | 0.2% |
Adenosine | ≤1.0% | 0.01% |
Total Impurities | ≤3.5% | 1.1% |
Solubility | Free solubility in water | Complies |
Particle Size | 100% through 60 mesh | Complies |
Lead(mg/kg) | ≤3.0 | Complies |
Arsenic(mg/kg) | ≤2.0 | Complies |
Cadmium(mg/kg) | ≤1.0 | Complies |
Mercury (mg/kg) | ≤0.1 | Complies |
Total Plate Count | ≤1000cfu/g | Complies |
Mold &Yeast | ≤100cfu/g | Complies |
E．Coli | Not Detected | Complies |
Salmonella | Not Detected | Complies |
| Conclusion | Compliance With USP 43 | |
Primary Applications
1. Mental Health Formulations
- - Depression and mood disorder supplements
- - Cognitive function enhancement
2. Liver Support Products
- - Detoxification and liver function formulas
- - NAFLD (Non-Alcoholic Fatty Liver Disease) management
3. Joint Health Solutions
- - Osteoarthritis pain management
- - Cartilage support formulations
4. Specialty Nutraceuticals
- - Methylation support supplements
- - Anti-aging and longevity products
What are the benefits of partnering with us for SAMe production?
✅ Certified Excellence
- Halal/Kosher, GMP, ISO 9001, and NSF certifications
- Meets the standards set by the USP-NF (USA), EP (Europe), and JP (Japan) pharmacopeias
- Full FDA DMF and EU CEP documentation support
✅ Uncompromised Quality
- Because it was manufactured with contemporary fermentation methods, wine is 99.3% to 99.8% pure.
- There are not many heavy metals or endotoxins in it (less than 0.05 EU/mg).
- You can keep a package that has been cleansed with nitrogen for 24 months.
✅ Solutions for Every Market
- North America: SAMe for dietary supplements (depression, osteoarthritis)
- Europe: Pharma-grade SAMe for liver health formulations
- Asia: Cost-optimized SAMe for generics and OTC products
Our Quality Promise
✅ 99.9% S Adenosyl Methionine Powder content via HPLC testing shows that the product is of pharmaceutical grade.
✅ The formula is stabilized, and the packaging protects it from oxidation, which is a common problem with SAMe.
✅ Sourcing ethically: made from non-GMO plants that are safe for vegans.
Ordering & Support
- - Minimum order quantity (MOQ): 1 kg for samples used in research and development and 100 kg or more for bulk manufacture.
- - We take two to three weeks to process standard orders.
- - Free Samples: Available with complete analytical documentation
FAQ
Q: How do you keep SAMe stable when it's in powder form?
A: Our unique stabilization method involves vacuum drying and processes that don't add antioxidants. When stored at 15–25°C, it only loses <2% of its value after 24 months.
Q: Can you make SAMe blends that work with enteric-coated tablets?
A: Yes! We sell pre-mixed SAMe with Eudragit® L100-55 or cellulose-based coatings that dissolve in a way that meets USP <711> standards.
Q: What testing is included in the Certificate of Analysis?
A: Every batch includes:
- Purity (HPLC)
- Heavy metals (ICP-MS)
- Residual solvents (GC)
- Microbial analysis (USP <61>)
Q: Do you support small trial orders?
A: Absolutely. We provide 100g–1kg samples with full documentation for R&D evaluation.
Ready to Elevate Your SAMe Formulations?
🌐 Global Reach: our US/EU/Asia warehouses
💡 Expert Support: Free formulation consulting and regulatory guidance
Contact Us Today
📧 Email: duke@hongdaherb.com
[Request a Sample] [Download Technical Dossier]
Key Differentiators in Every Gram of Our SAMe
- Stability: Does better than competitors in tests that speed up aging (40°C/75% RH)
- Traceability: a complete history of the raw materials from fermentation to packaging
- Sustainability: Packaging that can be recycled 100% and delivery that doesn't add to carbon emissions
For S Adenosyl Methionine Powder that turns formulation problems into market-ready successes, choose Hongda. Let’s build the next generation of SAMe-powered solutions together!
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