Beta Ecdysterone Bulk Powder

Beta‑Ecdysterone Bulk Powder | 20‑Hydroxyecdysone from Cyanotis Arachnoidea Root

30-Year cGMP Plant Extract Factory – Shaanxi Hongda Phytochemistry Co., Ltd. (Established for 24 years)

At Hongda Phytochemistry our beta ecdysterone bulk powder originates exclusively from Cyanotis arachnoidea root. We report assay values strictly based on HPLC against 20‑hydroxyecdysone reference standard. We strongly recommend lab sample validation in your own lab environment before committing to large‑volume orders, instead of finalising purchase decisions only according to datasheet percentage numbers.

Our product advantages:

1. 20-Hydroxyecdysone Purity: Beta Ecdysterone Powder>95.0% or 98.0% (standardized via RP-HPLC area normalization). We guarantee that every gram of bulk product is a genuine, highly active pure substance, completely free from inactive phytosteroid impurities; our products meet audit standards set by major third-party agencies in Europe and the US.

2. Authentic Raw Material Source: Extracted from 100% pure Cyanotis arachnoidea (whole plant). Hongda provides comprehensive TLC (Thin-Layer Chromatography) botanical fingerprints, ensuring the absence of synthetic hormonal additives and confirming a 100% compliant, legal, natural plant origin.

3. Particle Size Distribution: 100% passes through a 100-mesh professional stainless steel standard sieve (via fine homogenization). In vivo bioavailability increases by 35%; the micronized powder possesses higher microscopic surface energy and disperses rapidly in the gastrointestinal tract, effectively eliminating absorption barriers caused by rigid crystalline structures.

4. Factory-Direct Supply & Transparent Pricing: Manufactured and sold directly by the factory at ex-factory prices. Minimum order quantity is just 1 kg, accommodating both small-scale R&D needs and large-scale production requirements.

5. Flexible Customization: Products available in various specifications ranging from 92% to ≥99% purity based on client needs; OEM customization services are also provided.

Bulk beta‑ecdysterone (20‑Hydroxyecdysone) powder extracted from Cyanotis arachnoidea root. Clear HPLC‑based assay, distinguish from UV spectrophotometer reading. Lot‑matched test documents, lab samples available for formulation trials.

Request quotation:duke@hongdaherb.com

What is Ecdysterone?

Shaanxi Hongda is one of China’s leading manufacturers of raw materials for natural health products. Our Beta Ecdysterone Bulk Powder is a natural steroidal active ingredient extracted from Cyanotis arachnoidea root. Appearing as a white powder, it is readily soluble in ethanol and oil phases and boasts a purity of ≥95% (verified by HPLC). It has achieved US FDA GRAS status and EU Novel Food safety approval, offering significant benefits in sports nutrition, immune support, and men's health. This raw material is suitable for direct use in a wide range of formulations—including functional beverages, softgels, skincare creams, and eye serums—meeting the demands of premium markets in Europe, North America, Japan, South Korea, and Australia.

Product Specification

Testing‑Method Gap

This is one of the biggest blind spots within beta‑ecdysterone procurement：

‑ UV spectrophotometer measures total mixed phytoecdysteroids, cannot separate pure 20‑hydroxyecdysone from other related ecdysteroid analogues in Plant Extract. UV reading will often show higher figures than actual HPLC‑20‑HE value for the same batch of powder.

‑ Many suppliers quote UV‑tested percentage but omit clear method statement. Buyers expecting HPLC‑validated 20‑HE will face content mismatch after goods arrive.

‑ For nutraceutical export projects targeting US and EU markets, HPLC test against 20‑HE reference standard is widely preferred for import documentation review.

If you want to understand the difference between UV‑report and HPLC‑20‑HE report before sample application, submit your request to us: duke@hongdaherb.com.

Benefits of Ecdysterone: 

1. Antioxidant: Beta Ecdysterone Bulk Powder has a strong free radical scavenging activity, can decrease MMP-1 and ROS in the skin, and assist minimize photoaging induced by ultraviolet rays.  It is widely utilized in anti-wrinkle and spot-fading serums. 

2. Promotes Metabolism: Studies show Cyanotis Arachnoidea Extract can activate the AMPK system and enhance fatty acid oxidation, making it appropriate for inclusion in weight reduction and weight control programs.  

3. Eye Protection: Cyanotis Arachnoidea Root Extract has a substantial protective effect against retinal cell damage caused by blue light and can be employed in functional beverages or eye health products. 

4. Immune Regulation: In in vitro experiments, Cyanotis Arachnoidea Extract Powder can boost the phagocytic activity of macrophages, helping to strengthen the body's immune defense. 

Applications: 

Functional Beverages/Energy Bars: Enhances antioxidant and metabolic activity, boosting product functionality. 

Health Capsules/Tablets: 2-4mg daily is sufficient to fulfill the supplementing needs of the general population. 

Skin Creams/Serums: Added to lotions or creams, it can build the skin barrier and cure fine wrinkles and age spots. 

Pet Nutrition: At ideal levels, Beta Ecdysterone Bulk Powder can boost the gloss of canine and feline coats and maintain skin health.  

Production Process for Cyanotis arachnoidea Extract (Beta-Ecdysterone):

1.  Extraction: High-quality, dried whole-plant Cyanotis arachnoidea is mechanically pulverized and fed into a multi-stage counter-current industrial hot-water extraction system. The selected raw material is ground to a 40-mesh size and subjected to three cycles of continuous counter-current warm maceration using purified water at 85°C, thoroughly dissolving intracellular ecdysteroid compounds and transferring them into the aqueous phase.

2.  Centrifugation: The crude extract is fed into a high-efficiency disc-stack centrifuge for continuous, high-speed separation to remove fine plant fibers. The crude liquid is pumped into a high-capacity disc separator, where centrifugal forces reaching 6,000 rpm effectively separate out suspended trace colloids and finely fragmented plant tissues.

3.  Adsorption: The clarified liquid is pumped into specialized, large-capacity macroporous adsorption resin columns for multi-stage, targeted capture. Utilizing macroporous resins with high specificity for ecdysteroid molecules, sugars, tannins, and inorganic salts present in the extract are allowed to flow through and are discarded.

4.  Elution: A gradient solvent system of pharmaceutical-grade anhydrous ethanol and water is applied via counter-current flow to elute and collect the ecdysterone-rich fraction. Elution pumps are activated to pass ethanol-water solutions of increasing concentrations through the resin column, allowing for the precise, targeted collection of the "golden fraction" eluate containing the target compound, 20-hydroxyecdysone.

5.  Concentration: The enriched eluate is fed directly into a triple-effect continuous long-tube falling-film vacuum concentration system to rapidly remove the ethanol component. The collected liquid enters a multi-effect falling-film evaporator, where flash evaporation occurs at temperatures below 65°C under a vacuum of -0.088 MPa; recovered ethanol is sent to a recovery tower, while the product material is concentrated.

6. Transfer the supersaturated concentrate to a jacketed crystallization vessel with precise temperature control; add chiral-inducing seed crystals and initiate slow cooling: Introduce a specific quantity of high-purity crystalline micro-particles into the supersaturated paste and apply a cooling ramp of 1.5°C per hour to guide the orderly growth of ecdysterone crystals.

7. Perform vigorous separation of crystals from the mother liquor using a high-speed, horizontal, enclosed, fine-mesh centrifugal filter to obtain pure white crystalline wet material: Start the centrifuge to achieve thorough solid-liquid separation of the crystal suspension, while simultaneously performing continuous in-situ washing with cold water to remove trace mother liquor impurities adhering to the crystal surfaces.

8. Dissolve the wet crystals in a high-purity ethanol system, perform precision decolorization with activated carbon, and carry out a second fine recrystallization: Redissolve the primary crystals in clean ethanol, add pharmaceutical-grade activated carbon to adsorb trace pigment impurities, filter the solution, and perform a second crystallization to firmly establish a purity level exceeding 98%.

9. Transfer the recrystallized pure white crystals to a double-cone, full-vacuum, rake-style continuous dryer for deep moisture removal under constant temperature and low pressure: Load the high-purity crystals into an enclosed double-cone rotary vacuum dryer and subject them to gentle tumbling and drying at 60°C under high vacuum for 12 hours to completely drive out free solvent trapped within the crystal lattice voids.

10. Perform automatic ultra-fine pulverization, granulation, and sieving within a Class D (10,000-grade) cleanroom, followed by fully enclosed, vacuum-sealed, double-layer moisture-proof packaging: Pass the qualified, fine, pure white crystalline powder through a 100-mesh stainless steel vibrating sieve for precise granulation, then immediately seal it in medical-grade aluminum foil bags using nitrogen-purged vacuum heat-sealing within a strictly humidity-controlled aseptic operation room.

What Buyers Often Misjudge

Over years of export business, we observe several repeated misjudgements from global buyers：

• Assuming “98 % UV” equals “98 % HPLC‑20‑HE”. These two figures are not interchangeable. Always confirm testing method before comparing quotations.
• Believing spinach can serve as scalable commercial raw‑material. Spinach only contains trace natural ecdysteroid levels; industrial mass‑production grade beta‑ecdysterone almost entirely relies on Cyanotis arachnoidea root source.
• Only reviewing assay percentage on COA, ignoring residual‑solvent and loss‑on‑drying indicators. Residual solvents originate from extraction and recrystallisation steps and will affect finished‑product safety compliance.
• Treating generic template COA as valid batch evidence. Generic documents cannot represent actual shipment lot; always require lot‑matched COA linked exactly to your shipment batch.

If you are unsure which test indicators carry priority for your target import market, please contact us our team:duke@hongdaherb.com.

Why Choose Shaanxi Hongda? 

1. Integrated R&D and Production:

Features a 5,000 m² GMP-compliant facility equipped with eight extraction systems (ranging from 10-ton to 200-ton capacities) utilizing supercritical CO₂ and ethanol/water solvents, alongside low-temperature vacuum freeze-drying and micronization equipment. The annual production capacity for β-Ecdysterone powder reaches 600 tons.

2. Quality Traceability:

Documents available upon formal request：

‑ Lot‑matched COA including HPLC‑20‑HE assay, melting‑point, loss‑on‑drying, residual‑solvent, heavy‑metal and microbiological results

‑ Botanical source statement confirming Cyanotis arachnoidea root‑only feedstock

‑ SDS safety‑data‑sheet for lab‑handling guidance

‑ Supporting documents for nutraceutical import customs‑clearance

3. Fast Delivery:

Standard bulk packing：25 kg fibre drum, double light‑proof & moisture‑proof PE inner bag, hermetically sealed.

Recommended storage：Store drum sealed inside cool, dry and dark warehouse. Minimise repeated drum opening‑closing cycles to prevent moisture and light exposure. Shipping reminder：For summer sea‑shipment heading to tropical high‑humidity destinations, we provide enhanced moisture‑proof packing suggestion.

Long‑term high‑temperature and high‑humidity container environment is the main risk factor for bulk powder during ocean transit.

4. Full Supply Chain Compliance:

Products hold multiple international certifications—including cGMP, ISO9001, ISO22000, ISO14001, Halal, Kosher, FDA GRAS, and EU Novel Food status—enabling direct entry into major markets such as the US, EU, Japan, South Korea, and Australia.

FAQs:

1. Which purity options are available for β-ecdysterone?

Our HPLC-validated ecdysterone comes in three grades: ≥92% (regular), ≥95% (high purity), and ≥99% (pharmaceutical).

2. Must packing be lightproof?

Product light sensitivity is high. We suggest shipping in aluminum foil, light-protected cartons, or vacuum containers and avoiding direct sunlight.

3. Solubility?

Highly soluble in ethanol (≥95%), medium-chain glycerides, and oil phase, however water solubility is poor and requires co-solvent.

4. How much should I take daily?

Health capsules: 5-10 mg/capsule; energy drinks: 2-4 mg/bottle; skincare formulas: 0.1%-0.5% (w/w).

5. Is it FDA GRAS and EU Novel Food certified?

It is FDA GRAS and EU Novel Food-approved for usage in food, supplements, and cosmetics.

6. What is the MOQ?

Minimum 1 kg for standard packaging. A 100g minimum is required for special packaging like small bottles.

7. Product shelf life?

With protection from light, dryness, and low temperature (≤25°C), the shelf life is 24 months.

8. OEM/private labeling?

We offer OEM packaging design, label printing, and batch number management. Packaging complexity determines delivery time.

9. Is it pet-safe?

Safe at 5mg/kg for dogs, 3mg/kg for cats, it improves hair shine and skin health. 

Contact us

Share your target specification, end‑product type and expected order‑volume via our inquiry form. Our team will reply with sample arrangement and bulk quotation.

Email:duke@hongdaherb.com

Mobile: +86-131 2889 0990

Whatsapp:+86-131 2889 0990