16‑Dehydropregnenolone Acetate Powder | Bulk 16‑DPA Steroid Synthesis Intermediate, CAS 979‑02‑2

Bulk 16-Dehydro Pregnenolone Acetate Powder | 16‑DPA Pharmaceutical Intermediate‑ Hongda Phytochemistry

- CAS No：979‑02‑2

‑ Synonym：16‑DPA,3β‑Acetoxy‑5,16‑pregnadien‑20‑one

‑ Appearance：White crystalline powder

‑ Core test items：HPLC assay, melting point, loss on drying, residual solvents, heavy‑metal panel

‑ Solubility：Soluble in ethanol, methanol; practically insoluble in water

‑ Storage guidance：Sealed, dry, ventilated condition; avoid prolonged high‑temperature exposure

‑ Sample support：Lab‑scale samples for synthetic process validation before bulk order

‑ Primary use：Only for laboratory R&D and steroid intermediate synthesis; not for direct finished‑drug application

We offer 16-DPA (16-Dehydropregnenolone acetate) bulk powder—used in steroid synthesis—accompanied by batch-verified test reports covering HPLC, melting point, and residual solvents.

Request quotation:duke@hongdaherb.com

What is acetate of 16-dehydropregnenolone?

What is 16-dehydropregnenolone acetate? Shaanxi Hongda is a professional manufacturer specializing in the research and supply of active pharmaceutical ingredients (APIs). We sell 16-DPA powder, a sterol molecule whose absorption is blocked by 17α-hydroxylase and 5α-reductase after oral administration. 16-Dehydro Pregnenolone Acetate Powder is a potent antagonist of bile acid receptors (BAR) and farnesol X receptors (FXR), possessing lipid-lowering and anti-cancer properties. Furthermore, 16-dehydropregnenolone acetate (16-DPA) is also a raw material for the synthesis of dexamethasone (HY-14648) and other steroidal pharmacophores. We adhere to the latest ICH Q3C standards, employing a green solvent substitution method to ensure residue levels are far below pharmacopoeia limits, supporting your direct use in the research and production of export formulations.

16-DPA - Physico-chemical Properties: ​​​​​​​

Specifications: 

Need lab‑scale 16‑DPA sample or full set of lot‑matched test documentation? Please contact us:duke@hongdaherb.com.

Benefits of 16-Dehydropregnenolone Acetate:

1. Steroid hormone precursor: It can be converted to cortisol, progesterone, testosterone, estrone, and other hormones in the body or during processing. This maintains the balance of sex hormones, metabolism, and immunity.

2. Anti-inflammatory and Immunomodulatory Effects: 16-Dehydro Pregnenolone Acetate Powder can be employed in the drug development stage to make anti-inflammatory corticosteroids because it is a precursor to cortisone.

3. Metabolic Support: In scientific research, it is utilized to study how 16-substitution affects steroid metabolic enzymes (such CYP17A1) and helps find novel drugs.

Application Areas:

Practical Production & Lab‑Handling Notes

These notes are gathered from our industrial‑customer lab trials and pilot‑batch synthesis work：

1. 16‑DPA powder shows good stability under dry sealed conditions, yet long‑term exposure to high humidity will trigger partial caking. Once caked, physical crushing cannot fully reverse particle status and may affect dissolution performance in your synthetic solvent system. Always keep drums tightly sealed after material is taken out.
2. It dissolves well in organic solvents such as ethanol and methanol, but barely dissolves in water. Do not expect direct dissolution within aqueous reaction systems; pre‑dissolution in suitable organic solvent is required before feeding into your synthesis workflow。
3. Avoid sustained over‑heating during material transfer and pre‑processing. Though melting point sits around 165‑175℃, repeated local over‑heating below melting point may introduce unknown related‑substance impurities, which will increase purification workload in your downstream synthesis.
4. Dust‑forming risk exists during weighing and dispensing. Lab and production workshops need basic dust‑protection operation to prevent operator direct skin and eye contact。
5. Particle size will impact dissolving speed in your solvent. If you run continuous feeding or pilot synthesis, confirm particle‑size requirement in advance. Standard mesh may not satisfy high‑speed continuous feeding scenarios.
6. This material serves purely as a synthetic intermediate. It cannot be used directly as finished pharmaceutical raw material without further multi‑step chemical modification.

Why Choose Us?

1. Technical Support:

Shaanxi Hongda boasts 24 years of experience in synthesizing steroid hormone drug raw materials, providing comprehensive technical services including process scale-up, raw material formulation, crystal form control, and stability assessment.

2. Testing Reports:

‑ Lot‑matched COA including HPLC assay, melting‑point, loss on drying, residual‑solvent and heavy‑metal results

‑ Raw‑material source statement

‑ SDS safety data sheet for lab‑operation guidance

‑ Supporting documents for import customs clearance of fine‑chemical intermediates

‑ Lab‑size samples for synthetic‑process validation

3. Professional Team:

Our specialized laboratory comprises an interdisciplinary team of experts in pharmacy, chemistry, process engineering, and regulatory compliance, ensuring rapid response to formulation, process, and registration issues.

4. After-Sales Service:

Shaanxi Hongda has its own after-sales service team, providing 24/7 customer service hotline, logistics tracking, quality traceability, technical training, and formulation improvement suggestions. If batch discrepancies occur, a replacement of the same batch or a full refund can be provided within 48 hours.

FAQs:

1. How pure is 16-dehydropregnenolone acetate?

 16-Dehydro Pregnenolone Acetate Powder≥99% (USP<795>), HPLC test report for each batch.

2. Are there additives or fillers?

100% natural, crystalline powder without additives, sweeteners, or preservatives.

3. What is the powder's particle size and formulation suitability?

Particles ≤10µm (pharmaceutical grade) or ≤8µm (functional formulation) are ideal for capsules, tablets, drinks, gummies, and microencapsulation.

4. Minimum order quantity?

One-kg bulk orders, 300g-5kg moisture-proof containers.

5. How to obtain samples for formulation verification?

Free 50g (pharmaceutical grade) or 100g (functional formulation) samples are provided, provided there are large and stable orders in the future. A complete test report will be provided with the sample.

6. What if the received batch does not meet the quality requirements?

Following a complaint, our technical support team will verify the issue within 48 hours. Upon confirmation, we will provide a replacement of the same batch or a full refund, along with a quality analysis report.

7. What is the compliance status of this raw material in the European and American markets?

Our 16-DAP powder has received FDA GRAS notification and EU Novel Food approval, meeting the safety and quality requirements of the US FDA and EU EMA for steroid intermediates. It can be directly used in pharmaceutical research, functional foods, and health supplements.

8. What does powder caking indicate after goods arrive?

Caking usually means moisture intrusion during transit or storage. It may change dissolving behaviour in organic solvent, lab re‑evaluation is suggested before putting into production.

9. Can 16‑DPA be directly used to produce finished drug substances?

No. It acts only as key synthetic intermediate. Multi‑step chemical conversion is required before obtaining final API products.

How to contact us?

a. Online service: via Trade Manager, WhatsApp, or email：duke@hongdaherb.com.

b. You can select the products you are interested in and send us an inquiry.

c. Please do not hesitate to call us.

NOTE:This Is Exclusively For Use By Professional Institutions. It Is Not A Consumer Product. Unauthorized Purchase And Use By Individuals Is Prohibited.