Can Tongkat Ali affect sleep?

October 21, 2025

Struggling with restless nights, waking up exhausted, or experiencing inconsistent energy throughout the day? You're not alone in this sleep dilemma. Many health-conscious individuals seeking natural solutions wonder whether Tongkat Ali Extract could be the missing piece in their wellness routine. The answer is both fascinating and nuanced. Research demonstrates that Tongkat Ali Extract from Hongda Phytochemistry and Shaanxi Hongda Phytochemistry Co., Ltd. exhibits unique adaptogenic properties that can enhance sleep quality during resting periods while promoting wakefulness during active hours, creating a balanced circadian rhythm that supports overall vitality and hormonal health. Understanding how this powerful botanical extract influences your sleep-wake cycle is crucial for anyone considering supplementation, whether you're an athlete seeking recovery optimization, a professional managing stress, or simply someone pursuing better restorative sleep. This comprehensive guide explores the scientific evidence behind Tongkat Ali Extract's effects on sleep architecture, optimal timing strategies, and how to leverage this natural compound for maximum benefit without disrupting your nightly rest.

tongkat ali extract powder

 

Understanding Tongkat Ali Extract and Its Active Compounds

Tongkat Ali Extract, derived from the roots of Eurycoma longifolia, represents one of Southeast Asia's most treasured medicinal plants, with centuries of traditional use supporting vitality and wellness. The extract's therapeutic potential stems primarily from its bioactive compounds, particularly eurycomanone, which serves as the standardized marker for quality assessment. At Shaanxi Hongda Phytochemistry Co., Ltd., our Tongkat Ali Extract undergoes advanced extraction processes including countercurrent extraction, membrane separation, and column chromatography to achieve standardized concentrations ranging from one to ten percent eurycomanone content, with extraction ratios reaching an impressive two hundred to one. The root material contains multiple quassinoids beyond eurycomanone, including eurycomaoside and eurycomanone, which collectively contribute to the extract's adaptogenic properties. These compounds interact with multiple physiological systems, influencing hormonal balance, energy metabolism, and stress response mechanisms. The brown-yellow powder produced through our cGMP-standard facilities maintains consistent bioavailability, ensuring that each batch delivers predictable therapeutic effects. Understanding these active constituents helps explain why Tongkat Ali Extract produces seemingly contradictory effects on energy and sleep, as different compounds activate distinct biological pathways depending on circadian timing and individual physiology. Quality matters tremendously when discussing Tongkat Ali Extract's effects on sleep and wakefulness. Our manufacturing process at Shaanxi Hongda begins with carefully selected tongkat ali roots from sustainable sources, ensuring optimal eurycomanone content from the start. Through HPLC testing, we confirm minimum purity levels of one percent eurycomanone, with capabilities extending to ten percent for specialized formulations. This standardization proves critical because unstandardized or low-quality extracts may contain inconsistent compound profiles that produce unpredictable effects on sleep patterns. Every batch undergoes rigorous testing for heavy metals, with lead levels maintained below three milligrams per kilogram and arsenic below one milligram per kilogram, while microbiological screening ensures absence of E. coli and Salmonella, meeting international safety standards that protect consumer health during long-term supplementation.

  • The Science of Adaptogenic Sleep Regulation

Adaptogenic herbs like Tongkat Ali Extract function differently from sedatives or stimulants, working instead to normalize physiological functions regardless of the direction of imbalance. This bidirectional regulatory capacity explains how the same Tongkat Ali Extract can enhance alertness during waking hours while simultaneously improving sleep quality during rest periods. Recent scientific investigations have revealed that Tongkat Ali Extract modulates core body temperature fluctuations throughout the twenty-four-hour cycle, with elevations during active periods supporting wakefulness and declines during rest periods facilitating sleep onset and maintenance. This thermoregulatory effect synchronizes with natural circadian rhythms rather than overriding them, creating a more robust and resilient sleep-wake pattern. The adaptogenic mechanism extends to hormonal regulation, particularly involving cortisol and testosterone balance. Chronic stress typically elevates evening cortisol levels, which interferes with melatonin production and disrupts sleep architecture. Tongkat Ali Extract has demonstrated significant cortisol-reducing effects in moderately stressed individuals, helping restore the natural cortisol curve where levels should peak in the morning and decline toward evening. By normalizing this stress hormone pattern, the extract indirectly supports healthier sleep timing and quality. Simultaneously, the testosterone-supporting properties of Tongkat Ali Extract contribute to improved sleep efficiency, as optimal testosterone levels correlate with deeper sleep stages and enhanced recovery processes during the night. Research utilizing electroencephalography monitoring in animal models has documented that Tongkat Ali Extract supplementation increases both rapid eye movement sleep and delta wave activity during non-REM sleep phases when administered during resting periods. These sleep stages prove essential for memory consolidation, physical restoration, and hormonal regulation. The enhancement of sleep quality occurs without sedative effects that might impair next-day cognitive function or create dependency patterns common with pharmaceutical sleep aids. Instead, Tongkat Ali Extract appears to strengthen the natural sleep drive that accumulates during waking hours, making the transition to sleep more efficient when bedtime arrives while maintaining sleep continuity throughout the night.

 

How Tongkat Ali Extract Influences Sleep Architecture?

Sleep architecture refers to the cyclical pattern of sleep stages that occur throughout the night, including light sleep, deep sleep, and REM sleep phases. Each stage serves distinct physiological functions, and disruptions to this natural architecture result in unrefreshing sleep despite adequate time in bed. Tongkat Ali Extract influences sleep architecture through multiple mechanisms that collectively enhance both sleep quality and restorative capacity. The extract's effects on neurotransmitter systems, particularly those involving adenosine accumulation and clearance, play a fundamental role in regulating sleep pressure and sleep depth. By supporting efficient energy metabolism through ATP production, Tongkat Ali Extract helps maintain the adenosine signaling that promotes natural sleepiness when appropriate while preventing excessive daytime adenosine accumulation that causes fatigue. The relationship between Tongkat Ali Extract and REM sleep deserves particular attention, as this sleep stage proves critical for emotional regulation, memory processing, and cognitive function. Studies have documented significant increases in REM sleep duration following Tongkat Ali Extract supplementation during rest periods, suggesting enhanced activation of cholinergic neurons in the brainstem that generate REM sleep. This REM enhancement occurs alongside increased slow-wave sleep activity, indicated by elevated delta EEG power, which represents the deepest and most restorative sleep phase. The simultaneous improvement in both REM and deep sleep stages demonstrates Tongkat Ali Extract's comprehensive beneficial effects on sleep quality rather than simply sedating the nervous system or suppressing certain sleep phases as some sleep medications do. Individual responses to Tongkat Ali Extract regarding sleep architecture may vary based on baseline sleep quality, stress levels, and hormonal status. Persons experiencing stress-related sleep disruption often report the most dramatic improvements, as the extract's cortisol-moderating effects address a primary cause of their sleep difficulties. The high-quality Tongkat Ali Extract from Shaanxi Hongda Phytochemistry Co., Ltd., with its standardized eurycomanone content and comprehensive safety testing, provides consistent therapeutic effects that support predictable outcomes. Our manufacturing standards, including ISO22000, HACCP, Kosher, and Halal certifications, ensure that every batch delivers the bioactive compounds necessary for optimal sleep regulation without contaminants that might interfere with these delicate physiological processes.

  • Timing Strategies for Optimal Sleep Benefits

The timing of Tongkat Ali Extract administration significantly influences whether the extract primarily enhances wakefulness or facilitates sleep, making strategic supplementation timing essential for achieving desired outcomes. Research indicates that the extract's effects transition rapidly between wake-promoting and sleep-enhancing depending on circadian phase, suggesting that the body's internal biological clock modulates responsiveness to the bioactive compounds. For individuals seeking primarily sleep-enhancing benefits, evening administration approximately two to three hours before bedtime allows the extract's cortisol-reducing and temperature-modulating effects to align with the natural evening decline in these parameters. This timing strategy capitalizes on the extract's ability to facilitate the physiological transition from wakefulness to sleep readiness. Conversely, individuals who experience mild stimulating effects from Tongkat Ali Extract or who prioritize its energy-enhancing and cognitive benefits may prefer morning or early afternoon administration, typically before two o'clock in the afternoon. This earlier timing ensures that any wake-promoting effects support daytime alertness and productivity while minimizing potential interference with evening sleep onset. The adaptogenic nature of quality Tongkat Ali Extract means that even with morning administration, many users still experience improved nighttime sleep quality through indirect mechanisms including stress reduction, hormonal balance optimization, and enhanced energy metabolism that prevents the compensatory fatigue that often disrupts sleep patterns. The key involves consistent timing that allows your body to establish predictable patterns of extract exposure aligned with your natural circadian rhythm. Individual experimentation remains valuable given the variability in personal circadian chronotypes, stress levels, and metabolic rates. Starting with a lower dosage of Tongkat Ali Extract, such as two hundred milligrams daily of our standardized product containing minimum two percent eurycomanone, allows assessment of personal timing sensitivity before advancing to the standard four hundred milligram dose commonly used in research studies. Maintaining consistent administration times for at least two weeks provides sufficient time for adaptogenic effects to fully develop and for your sleep-wake patterns to stabilize around the supplementation schedule. The flexibility of Shaanxi Hongda's Tongkat Ali Extract formulations, available in powder, capsule, and tablet forms, facilitates precise timing adjustments to match individual needs and preferences while maintaining the therapeutic compound delivery necessary for optimal sleep and wakefulness regulation.

 

Tongkat Ali Extract for Stress-Related Sleep Disruption

Chronic stress represents one of the most common causes of sleep disturbance in modern society, with elevated evening cortisol levels directly interfering with the natural transition to sleep. Tongkat Ali Extract has demonstrated remarkable efficacy in addressing stress-related sleep disruption through its proven cortisol-moderating properties. Clinical studies involving moderately stressed individuals have documented significant reductions in cortisol levels following Tongkat Ali Extract supplementation, accompanied by improvements in tension, anger, and confusion mood states. These psychological benefits directly translate to improved sleep initiation and maintenance, as the racing thoughts and physical tension associated with elevated stress hormones diminish, allowing the natural sleep drive to predominate when bedtime arrives. The mechanism underlying Tongkat Ali Extract's stress-reducing effects involves modulation of the hypothalamic-pituitary-adrenal axis, the primary system governing the body's stress response. By supporting healthy feedback regulation within this axis, the extract helps prevent the chronic HPA activation that characterizes prolonged stress conditions. This regulatory effect differs fundamentally from sedative approaches that simply suppress nervous system activity without addressing underlying stress physiology. The result is restored resilience to daily stressors and normalized cortisol patterns that support both daytime function and nighttime recovery. Users of high-quality Tongkat Ali Extract from Shaanxi Hongda Phytochemistry Co., Ltd. often report feeling simultaneously more calm during stressful situations and more naturally energized during the day, with the cumulative effect being easier sleep onset and more restorative sleep throughout the night. Combining Tongkat Ali Extract with complementary stress-management practices amplifies its sleep-supporting benefits. The extract provides biochemical support for stress resilience while behavioral interventions like meditation, regular exercise, and consistent sleep schedules reinforce healthy circadian patterns. Our Tongkat Ali Extract, manufactured in cGMP-certified facilities with comprehensive quality testing including pesticide residue detection through third-party agencies like SGS and Eurofins, ensures that your stress management and sleep optimization efforts are supported by a pure, potent botanical extract free from contaminants that might otherwise undermine health goals. The brown-yellow powder passes through eighty mesh screening and maintains less than five percent moisture content, guaranteeing consistent bioavailability that allows the active eurycomanone and related quassinoids to effectively modulate stress hormones and support restorative sleep patterns over extended supplementation periods.

  • Hormonal Balance and Sleep Quality Connection

The intricate relationship between hormonal balance and sleep quality becomes particularly evident when examining testosterone's role in sleep architecture and recovery. Research has consistently demonstrated that healthy testosterone levels correlate with improved sleep efficiency, greater amounts of deep sleep, and better overall sleep quality in both men and women, though effects prove most pronounced in males. Tongkat Ali Extract's well-documented testosterone-supporting properties therefore indirectly contribute to sleep enhancement through this hormonal pathway. The extract facilitates the release of free testosterone from binding proteins, increasing the bioavailable fraction that can interact with cellular receptors throughout the body, including those involved in sleep regulation. This mechanism operates independently of the extract's direct effects on sleep architecture, creating complementary pathways through which supplementation improves nighttime rest. The testosterone-sleep relationship functions bidirectionally, with poor sleep also suppressing testosterone production, particularly when sleep restriction occurs chronically. This creates a potential negative cycle where declining testosterone contributes to worsening sleep, which further reduces testosterone levels. Tongkat Ali Extract may help break this cycle by supporting testosterone production even in the context of mild sleep deficiency while simultaneously improving sleep quality through its other mechanisms. The result is a positive feedback loop where hormonal optimization supports better sleep, which in turn facilitates continued hormonal health. For individuals experiencing age-related testosterone decline or stress-induced suppression of testosterone production, incorporating quality Tongkat Ali Extract may provide dual benefits for both hormonal vitality and sleep restoration. Shaanxi Hongda Phytochemistry Co., Ltd. produces Tongkat Ali Extract specifically formulated to support hormonal health through standardized eurycomanone content, the primary bioactive compound responsible for testosterone-supporting effects. Our extraction ratio of two hundred to one ensures concentrated delivery of these beneficial compounds, while our rigorous quality control processes verify that each batch maintains the specified potency range between one and ten percent eurycomanone as confirmed by HPLC testing. This standardization proves essential because testosterone-supporting effects depend on adequate delivery of active compounds, and unstandardized extracts may contain insufficient eurycomanone to produce meaningful hormonal or sleep benefits. The comprehensive certifications we maintain, including ISO9001, FSSC22000, and organic certifications from both EU and NOP standards, reflect our commitment to producing Tongkat Ali Extract that reliably delivers the hormonal and sleep-supporting properties that make this botanical extract valuable for health-conscious individuals worldwide.

Tongkat ali extract benefits

Safety Considerations and Optimal Dosing for Sleep Support

Understanding appropriate dosing parameters and safety considerations ensures that Tongkat Ali Extract supplementation supports sleep without causing adverse effects or unexpected outcomes. The majority of clinical research investigating Tongkat Ali Extract's effects has utilized dosages between two hundred and four hundred milligrams daily of standardized extract, with four hundred milligrams representing the most commonly studied dose for hormonal and sleep-related benefits. At these research-validated dosages, the extract demonstrates excellent safety profiles with minimal reported adverse effects when products meet quality standards comparable to those maintained by Shaanxi Hongda Phytochemistry Co., Ltd. Starting at the lower end of this range allows individual assessment of response patterns before advancing to higher dosages, particularly important for persons sensitive to supplements or those using Tongkat Ali Extract for the first time. Consistency in daily administration appears more important than precise dosage timing for achieving optimal sleep-supporting effects, though as discussed previously, circadian timing still influences whether wake-promoting or sleep-enhancing effects predominate. Taking Tongkat Ali Extract at approximately the same time each day, whether morning or evening based on individual response patterns, allows your body to integrate the extract's adaptogenic effects into your natural physiological rhythms. The duration of supplementation also matters, with most benefits accumulating over several weeks of consistent use as hormonal balance normalizes and stress response patterns improve. Cycling strategies remain debated in the literature, with some experts recommending continuous supplementation while others suggest periodic breaks every eight to twelve weeks, though current evidence does not definitively establish the necessity of cycling for safety or efficacy maintenance. Safety screening proves paramount when selecting Tongkat Ali Extract products, as contamination with heavy metals, pesticides, or microbial pathogens could undermine health rather than supporting it. Our manufacturing processes at Shaanxi Hongda incorporate multiple safety checkpoints beginning with raw material testing and extending through finished product verification. Heavy metal content undergoes atomic absorption spectrophotometry to confirm levels remain well below international safety thresholds, while pesticide residue detection through partnerships with authorized third-party testing agencies including SGS and Eurofins ensures agricultural chemical residues do not compromise product purity. Microbiological testing screens for E. coli, Salmonella, and other pathogens, with all results documented in batch-specific Certificates of Analysis available to wholesale buyers. These comprehensive safety measures mean that when you source Tongkat Ali Extract from our China-based manufacturing facility, you receive a product that supports sleep and hormonal health without introducing contaminants that might otherwise disrupt these delicate physiological processes.

  • Potential Interactions and Contraindications

While Tongkat Ali Extract demonstrates excellent safety in healthy populations, certain considerations apply to individuals with specific health conditions or those taking particular medications. Persons with hormone-sensitive conditions should consult healthcare providers before beginning supplementation, as the extract's testosterone-supporting properties could theoretically influence conditions responsive to hormonal changes. Similarly, individuals taking medications that affect hormone levels, including hormone replacement therapies or hormonal contraceptives, should discuss potential interactions with qualified medical professionals to ensure compatibility. The extract's cortisol-moderating effects also warrant consideration for persons taking corticosteroid medications or those with conditions affecting adrenal function, though clinical evidence of problematic interactions remains limited in the literature. The mild stimulating effects some individuals experience with Tongkat Ali Extract suggest caution when combining with other stimulants or energy-enhancing supplements, particularly if sleep difficulties emerge. Combinations with caffeine-containing products should be monitored, as the additive effects might produce excessive stimulation in sensitive individuals. Conversely, the extract generally combines well with other sleep-supporting supplements like magnesium, glycine, or theanine for individuals seeking comprehensive sleep support. Our Tongkat Ali Extract from Shaanxi Hongda can be formulated in combination products that pair synergistic botanicals like Maca root or Ashwagandha, creating comprehensive adaptogenic blends that address multiple aspects of stress resilience and sleep quality. These combination possibilities reflect the versatility and safety profile of quality Tongkat Ali Extract when manufactured to rigorous standards. Pregnancy and lactation represent periods when supplementation requires particular caution, and insufficient safety data exists regarding Tongkat Ali Extract use during these life stages. The general recommendation advises avoiding Tongkat Ali Extract supplementation during pregnancy and breastfeeding unless specifically directed by a healthcare provider familiar with both the botanical extract and the individual's health status. For all other populations, monitoring individual response patterns during initial supplementation remains the most practical approach to ensuring compatibility and optimal outcomes. Starting with lower dosages, maintaining consistent timing, and allowing several weeks for full adaptogenic effects to develop provides the foundation for safe, effective use of Tongkat Ali Extract for sleep support and overall vitality enhancement.

 

Comparing Tongkat Ali Extract to Other Sleep Support Supplements

The supplement marketplace offers numerous options for individuals seeking natural sleep support, making comparative understanding valuable for informed selection. Tongkat Ali Extract occupies a unique position among sleep supplements because its primary mechanisms involve hormonal optimization and stress modulation rather than direct sedation or melatonin pathway activation. This distinguishes it from supplements like melatonin, which directly influences circadian timing and sleep initiation but does not address underlying hormonal or stress-related causes of sleep disruption. Tongkat Ali Extract also differs from anxiolytic herbs like valerian or passionflower that primarily work through GABAergic pathways to reduce nervous system arousal. The extract's adaptogenic approach offers advantages for persons whose sleep difficulties stem from hormonal imbalances, chronic stress, or circadian rhythm disturbances rather than simply excessive nervous system activation. Comparing Tongkat Ali Extract to other adaptogenic herbs reveals both similarities and distinctions. Ashwagandha, another popular adaptogen, shares cortisol-moderating properties with Tongkat Ali Extract but exerts less pronounced effects on testosterone levels, making it potentially more suitable for women seeking stress support without androgenic effects. Rhodiola rosea provides wake-promoting and anti-fatigue benefits similar to Tongkat Ali Extract's daytime effects but lacks the same sleep-enhancing properties during rest periods. Combining Tongkat Ali Extract from Shaanxi Hongda Phytochemistry Co., Ltd. with complementary adaptogens creates comprehensive formulations that address multiple aspects of stress resilience and circadian regulation. Our custom formulation services allow B2B clients to develop proprietary blends that combine our high-quality Tongkat Ali Extract with other botanicals, creating unique products positioned for specific market segments. Quality considerations prove especially important when comparing Tongkat Ali Extract products across suppliers. Standardization to eurycomanone content ensures consistent therapeutic effects, while extraction methods influence the compound profile and bioavailability of the final product. The advanced extraction technologies employed at Shaanxi Hongda, including countercurrent extraction and membrane separation, produce Tongkat Ali Extract with superior compound concentration and purity compared to simple hot water extractions or alcohol tinctures. Our two hundred to one extraction ratio means that every gram of extract represents two hundred grams of original root material, providing concentrated delivery of bioactive compounds in smaller serving sizes. Combined with our comprehensive testing protocols and international certifications including cGMP, FSSC22000, ISO22000, and organic certifications, our China Tongkat Ali Extract factory delivers a superior product that justifies premium positioning for brands seeking the highest quality Tongkat Ali Extract for their formulations.

  • Real-World Applications and User Experiences

Understanding theoretical mechanisms provides important context, but real-world applications and user experiences offer practical insights into how Tongkat Ali Extract functions in daily life. Athletes and fitness enthusiasts frequently incorporate Tongkat Ali Extract into their supplement regimens primarily for testosterone support and recovery enhancement, but many report unexpected improvements in sleep quality as a welcome secondary benefit. The combination of reduced cortisol levels from training stress and optimized testosterone production creates favorable conditions for deep, restorative sleep that supports muscle recovery and performance adaptation. These users often prefer morning administration of Tongkat Ali Extract to capitalize on its energy-supporting effects during training while still experiencing sleep benefits at night through the hormonal optimization pathway. Professionals experiencing work-related stress represent another population finding value in Tongkat Ali Extract supplementation for sleep support. The demands of high-pressure careers often disrupt normal cortisol patterns, with elevated evening levels making it difficult to transition from work mode to relaxation and sleep. Users in this category frequently report that Tongkat Ali Extract helps them feel more resilient to daily stressors while simultaneously improving their ability to "switch off" mentally when bedtime arrives. The extract's effects on both physiological stress markers and subjective stress perception create comprehensive support for individuals navigating demanding professional environments. Evening administration approximately two to three hours before bedtime often works well for this population, allowing the cortisol-moderating effects to facilitate the natural wind-down process. Middle-aged and older adults seeking to address age-related changes in hormonal status and sleep architecture comprise another key demographic for Tongkat Ali Extract supplementation. The simultaneous decline in testosterone production and degradation of sleep quality that often accompany aging create interrelated problems that the extract's dual mechanisms effectively address. Users in this age range commonly report improvements in sleep continuity, meaning fewer nighttime awakenings and easier return to sleep when awakenings do occur. The Tongkat Ali Extract from Shaanxi Hongda Phytochemistry Co., Ltd., with its guaranteed potency and comprehensive safety testing, provides the quality assurance particularly important for older adults who may have multiple health considerations and medication regimens. Our extensive certifications and third-party testing documentation support informed decision-making for this demographic and their healthcare providers.

 

Conclusion

The relationship between Tongkat Ali Extract and sleep proves more nuanced than simple stimulation or sedation, reflecting the extract's sophisticated adaptogenic properties that support physiological optimization rather than pharmacological override of natural functions. Evidence demonstrates that quality Tongkat Ali Extract, particularly products manufactured to the standards maintained by Shaanxi Hongda Phytochemistry Co., Ltd., can enhance sleep architecture during rest periods through multiple complementary mechanisms including cortisol modulation, testosterone optimization, and circadian rhythm regulation. Simultaneously, the extract supports daytime wakefulness and energy levels, creating a more robust and resilient sleep-wake pattern rather than simply inducing drowsiness. This dual functionality makes Tongkat Ali Extract particularly valuable for individuals experiencing stress-related sleep disruption, age-related hormonal decline, or athletes seeking both performance enhancement and recovery optimization. Strategic timing of supplementation, consistent daily administration, and sourcing from reputable manufacturers ensuring standardized eurycomanone content and comprehensive safety testing represent the keys to successfully incorporating this powerful botanical extract into a comprehensive wellness approach.

Ready to experience the sleep-enhancing and vitality-supporting benefits of premium Tongkat Ali Extract? As a leading China Tongkat Ali Extract manufacturer and China Tongkat Ali Extract supplier, Shaanxi Hongda Phytochemistry Co., Ltd. offers high quality Tongkat Ali Extract for sale at competitive wholesale prices. Our China Tongkat Ali Extract factory produces standardized extracts with verified eurycomanone content, comprehensive safety testing, and extensive international certifications supporting global regulatory compliance. Contact duke@hongdaherb.com today for samples, detailed Certificates of Analysis, and volume pricing on our premium Tongkat Ali Extract.

 

References

1. Talbott SM, Talbott JA, George A, Pugh M. Effect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition, 2013.

2. Ono M, Nishino N, Komi K, Kuroki Y, Sakai N, Nishino S. Eurycoma longifolia (Tongkat Ali) enhances wakefulness during active periods but facilitates sleep during resting periods in C57BL/6 mice. European Journal of Neuroscience, 2023.

3. Sakai N, Komi K, Nishino N, Kuroki Y, Nishino S. Eurycoma longifolia (Tongkat Ali) supplementation enhances sleep and wake consolidation in wild-type, but not in narcoleptic mice. Sleep Advances, 2024.

4. Henkel RR, Wang R, Bassett SH, Chen T, Liu N, Zhu Y, Tambi MI. Tongkat Ali as a potential herbal supplement for physically active male and female seniors - a pilot study. Phytotherapy Research, 2014.

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